These days, my answer is if it's really primarily of interest to a very cosmopolitan philanthropist trying to help the whole future, and there's no one client and it's not frontier advancing, then I think that does make it pretty plausible to me that there's no one doing it. We would love to change that, at least somewhat, by funding what we think is the most important work." - Meaning and context.">
In an interview with Robert Wiblin, February 2018; also quoted by Ben Pace in "Extended Quote on the Institution of Academia" and by Rob Bensinger in "Karnofsky on forecasting and what science does"
“

I think it's somewhat of a happy coincidence so far that most breakthroughs have been good. To say, I see a breakthrough on the horizon. Is that good or bad? How can we prepare for it? That's another thing academia is really not set up to do. Academia is set up to get the breakthrough. That is a question I ask myself a lot is here's an intellectual activity. Why can't it be done in academia? These days, my answer is if it's really primarily of interest to a very cosmopolitan philanthropist trying to help the whole future, and there's no one client and it's not frontier advancing, then I think that does make it pretty plausible to me that there's no one doing it. We would love to change that, at least somewhat, by funding what we think is the most important work.

— Holden Karnofsky

What It Means

This is a placeholder explanation generated by the low-overhead model. It interprets "I think it's somewhat of a happy coincidence so far that most breakthroughs have been good. To say, I see a breakthrough on the horizon. Is that good or bad? How can we prepare for it? That's another thing academia is really not set up to do. Academia is set up to get the breakthrough. That is a question I ask myself a lot is here's an intellectual activity. Why can't it be done in academia? These days, my answer is if it's really primarily of interest to a very cosmopolitan philanthropist trying to help the whole future, and there's no one client and it's not frontier advancing, then I think that does make it pretty plausible to me that there's no one doing it. We would love to change that, at least somewhat, by funding what we think is the most important work." in the context of "In an interview with Robert Wiblin, February 2018; also quoted by Ben Pace in "Extended Quote on the Institution of Academia" and by Rob Bensinger in "Karnofsky on forecasting and what science does"" to mean that wisdom is timeless.

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Source: Wikiquote: "Holden Karnofsky" (Quotes) The 'What it means' explanation text was generated by Google Gemini Flash (accessed January 18, 2026). https://gemini.google.com/app
Holden Karnofsky

About Holden Karnofsky

Holden Karnofsky is an American nonprofit executive. He is a co-founder and co-chief executive officer of the research and grantmaking organization Open Philanthropy. Karnofsky co-founded the charity evaluator GiveWell with Elie Hassenfeld in 2007 and is vice chair of its board of directors.