I model the world as having most of the impact from extreme cases, 'home-runs'. I think that's true in business, science and social impact. If you have good personal fit, your chances of being that extreme case are dramatically better – you climb the ladder, you get to see and do things that other can't, and you get to make unique contributions." - Meaning and context.">
QuotesCosmos
In an interview with Benjamin Todd, January 2014
“

I model the world as having most of the impact from extreme cases, 'home-runs'. I think that's true in business, science and social impact. If you have good personal fit, your chances of being that extreme case are dramatically better – you climb the ladder, you get to see and do things that other can't, and you get to make unique contributions.

— Holden Karnofsky

What It Means

This is a placeholder explanation generated by the low-overhead model. It interprets "I model the world as having most of the impact from extreme cases, 'home-runs'. I think that's true in business, science and social impact. If you have good personal fit, your chances of being that extreme case are dramatically better – you climb the ladder, you get to see and do things that other can't, and you get to make unique contributions." in the context of "In an interview with Benjamin Todd, January 2014" to mean that wisdom is timeless.

Source: Wikiquote: "Holden Karnofsky" (Quotes) The 'What it means' explanation text was generated by Google Gemini Flash (accessed January 18, 2026). https://gemini.google.com/app

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#Holden Karnofsky#extreme#impact#contributions#dramatically#homeruns#business#personal#science#chances#having#social
Holden Karnofsky

About Holden Karnofsky

Holden Karnofsky is an American nonprofit executive. He is a co-founder and co-chief executive officer of the research and grantmaking organization Open Philanthropy. Karnofsky co-founded the charity evaluator GiveWell with Elie Hassenfeld in 2007 and is vice chair of its board of directors.